Tony Mowbray’s side were beaten 1-0 by Cardiff last time out, following a run of three consecutive wins.
Wednesday are bottom of the table after taking just two points from their first eight league games this season.
Here’s the latest injury and team news from both camps:
1. Dennis Cirkin (Sunderland) - OUT
Cirkin has been sidelined since November with a hamstring injury and underwent surgery on the issue. The full-back has returned to training but won't be risked after a lengthy setback. Photo: Frank Reid
2. Michael Ihiekwe (Sheffield Wednesday) - DOUBT
Ihiekwe, who has made 25 Championship appearances this season, wasn't named in the squad for Wednesday's match against West Brom following a setback. The central defender has trained this week ahead of the Sunderland match. Photo: Naomi Baker
3. Nazariy Rusyn (Sunderland) - OUT
Rusyn has missed Sunderland's last eight matches with a calf issue. The forward has also trained this week but won't be risked for the Sheffield Wednesday fixture. Photo: Frank Reid
4. Ian Poveda (Sheffield Wednesday) - DOUBT
The Leeds loanee has missed Wednesday's last four matches with a hamstring injury but has been doing work on the grass at Wednesday's Middlewood Road training ground ahead of the Sunderland fixture. Photo: David Rogers